Citrullination and Carbamylation in the Pathophysiology of Rheumatoid Arthritis
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چکیده
منابع مشابه
Citrullination and Carbamylation in the Pathophysiology of Rheumatoid Arthritis
The discovery that citrullination was crucial for the recognition of antigens by the most disease-specific class of autoantibodies in rheumatoid arthritis (RA) had a huge impact on studies aimed at understanding autoimmunity in this disease. In addition to the detailed characterization of anti-citrullinated protein antibodies, various studies have addressed the identity of citrullinated antigen...
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Coronary heart disease is the main cause of mortality in patients with rheumatoid arthritis (RA), a disease known to be associated with accelerated atherosclerosis. The role of inflammation and immunity in atherosclerotic process offers possible explanations for the increased cardiovascular risk in patients with RA. The immune response to citrullinated peptides has been extensively studied in R...
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Citrullination and the immune response to citrullinated proteins have been fundamental for the early recognition of rheumatoid arthritis by serological tests and a better understanding of its pathophysiology. In the first years after the initial publications, the focus was on the antibodies directed to citrullinated proteins. It is now realized that citrullinating enzymes and citrullinated prot...
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this issue, Makrygiannakis and colleagues study the eff ect on synovial citrullination of treatment with two commonly used drugs in the treatment of rheumatoid arthritis (RA) [1]. Th ey found by immuno histo chemistry that intracellular citrullination, as deter mined by F95 antibody staining, as well as peptidyl arginine deiminase (PAD) expression were correlated with measures of synovial infl ...
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Rheumatoid Arthritis (RA) and chronic and aggressive periodontitis are chronic inflammatory disorders characterized by deregulation of the host inflammatory response. Increased secretion of pro-inflammatory mediators results in soft and hard tissue destruction of the synovium and periodontium respectively. Both diseases share risk factors and have pathological pathways in common, resulting in l...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2015
ISSN: 1664-3224
DOI: 10.3389/fimmu.2015.00192